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Excedrin Extra Strength, 300 Caplets


Acetaminophen, Aspirin (NSAID) and Caffeine Tablets, Pain Reliever/Pain Reliever Aid

Item #100017155

  • Available at your local Costco warehouse. Not available for purchase on

    With two different kinds of pain relievers in every pill, plus a booster to enhance headache relief, Excedrin ends headaches fast.

    For additional headache relief, try resting in a dark room and massaging the neck muscles to alleviate tension and tightness. Be sure to get enough sleep and exercise, reduce stress at home and work, eat a healthy diet and relax.

    Product Information:
    Uses: Temporarily relieves minor aches and pains due to:
    • Headache             
    • A Cold
    • Arthritis         
    • Muscular aches       
    • Toothache            
    • Premenstrual & menstrual cramps

    • do not use more than directed
    • adults and children 12 years and over:  take 2 caplets every 6 hours; not more than 8 caplets in 24 hours.
    • children under 12 years of age: ask a doctor  
    Active Ingredients (in each caplet) – Purpose:
    • Acetaminophen 250 mg – Pain reliever
    • Aspirin 250 mg (NSAID*) – Pain reliever
    • Caffeine 65 mg – Pain reliever aid

    *Nonsteroidal anti-inflammatory drug

    Inactive Ingredients:
    Carnauba Wax, Crospovidone, FD&C Blue #1 Aluminum Lake, Hypromellose, Microcrystalline Cellulose, Povidone, Pregelatinized Starch, Propylene Glycol, Saccharin Sodium, Stearic Acid, Titanium Dioxide.

    Reye’s syndrome:  Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product.  When using this product, if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye’s syndrome, a rare but serious illness.

    Allergy Alert:  Aspirin may cause a severe allergic reaction which may include:  hives, facial swelling, asthma (wheezing), and shock

    Liver Warning:
    This product contains acetaminophen. Severe liver damage may occur if you take
    • more than 2 caplets in 24 hours, which is the maximum daily amount
    • with other drugs containing acetaminophen
    • 3 or more alcoholic drinks every day while using this product

    Stomach Bleeding Warning:
    This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you
    • are age 60 or older
    • have had stomach ulcers or bleeding problems
    • take a blood thinning (anticoagulant) or steroid drug
    • take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others)
    • have 3 or more alcoholic drinks every day while using this product
    • take more or for a longer time than directed

    Caffeine Warning:
    The recommended dose of this product contains about as much caffeine as a cup of coffee. Limit the use of caffeine-containing medications, foods, or beverages while taking this product because too much caffeine may cause nervousness, irritability, sleeplessness, and, occasionally, rapid heartbeat.

    Do not use:
    • if you have ever had an allergic reaction to acetaminophen, aspirin or any other pain reliever/fever reducer
    • with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.         

    Ask a doctor before use if
    • you have liver disease
    • stomach bleeding warning applies to you
    • you have a history of stomach problems, such as heartburn
    • you have high blood pressure, heart disease, liver cirrhosis, or kidney disease
    • you are taking a diuretic
    • you have asthma

    Ask a doctor or pharmacist before use if you are taking:
    • a prescription drug for diabetes, gout, or arthritis
    • any other drug, or are under a doctor’s care for any serious condition

    Stop use and ask a doctor if
    • an allergic reaction occurs.  Seek medical help right away.
    • you experience any of the following signs of stomach bleeding:
      feel faint     vomit blood     have bloody or black stools
      have stomach pain that does not get better                
    • ringing in the ears or loss of hearing occurs   
    • painful area is red or swollen                                           
    • pain gets worse or lasts for more than 10 days         
    • fever gets worse or lasts for more than 3 days     
    • any new symptoms occur    
    These could be signs of a serious condition          

    If pregnant or breast-feeding, ask a health professional before use. It is especially important not to use aspirin during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.  

    Keep out of reach of children.  
    In case of overdose, get medical help or contact a Poison Control Center right away. Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.                                                                                       

    Other Information
    • store at 20°-25°C (68°-77°F)
    • read all product information before using.  Keep this box for important information.